0312国际期刊速递丨今日热点脑啡肽

TODAY今日发布BMCCardiovascDisordDec01,:19(1)今日发布01篇（共计55篇）BasicResCardiolMay01,:(3)今日发布01篇（共计03篇）JACCMar12,:73(9_Supplement_2),1-21今日发布21篇HighBloodPressCardiovascPrevEarlyRecent,Mar11,今日发布01篇CirculationMar12,:(11)今日发布17篇JIntervCardElectrophysiolEarlyRecent,Mar12,今日发布01篇RECOMMEND推荐阅读01血管紧张素受体脑啡肽酶抑制剂治疗功能性二尖瓣反流Circulationresearch-articleDuk-HyunKang,Sung-JiPark,etc.17小时前Background:Themorbidityandmortalityofpatientswithfunctionalmitralregurgitation(MR)remainhigh,butnopharmacologicaltherapyhasbeenproveneffective.Thehypothesisofthisstudywasthatsacubitril/valsartanwouldbesuperiortovalsartanaloneinimprovingfunctionalMRviadualinhibitionoftherenin-angiotensinsystemandneprilysin.功能性二尖瓣反流（MR）患者的发病率和死亡率仍然很高，但没有药物治疗被证明是有效的。本研究的假设是，通过对肾素-血管紧张素系统和尼泊尔蛋白酶的双重抑制，sacubitril/valsartan在改善功能性磁共振方面优于单独使用valsartan。Methods:Inthisdouble-blindtrial,werandomlyassignedpatientswithheartfailurewithchronicfunctionalMRsecondarytoleftventricular(LV)dysfunctiontoreceiveeithersacubitril/valsartanorvalsartan,inadditiontostandardmedicaltherapyforheartfailure.TheprimaryendpointwasthechangeineffectiveregurgitantorificeareaoffunctionalMRfrombaselinetothe12-monthfollow-up.Secondaryendpointsincludedchangesinregurgitantvolume,LVend-systolicvolume,LVend-diastolicvolume,andin